Abstract. In this article the author examines the process of revising the Latin American vector of US foreign policy under the presidency of Donald Trump. In particular, the paper analyzes the economic and political aspects of a new US policy in the Latin American region. The main focus of the research is on the reorganization of US economic relations with the countries of the region and cancellation of various financial aid programs and multilateral agreements, including the North American Free Trade Agreement. The main hypothesis of the paper is that US foreign policy under the 45th president underwent a profound change towards diminishing the role of the Latin American region among other foreign policy priorities of the United States. Vivid confrontation with China and the Russian Federation became the center of the contemporary foreign policy course of Washington, making relations with Latin American countries of secondary importance. This shift created a certain power vacuum in the region and opened additional opportunities for extraregional players. China could arguably become one of such players as it is known to have utilized Washington’s weakening grip on the region to its own economic and political benefit, expanding the “One belt, one road” initiative.