Abstract. The war in Nagorno-Karabakh of autumn 2020 which has already been called Second Karabakh or 44-days war led to noticeable changes in the balance of forces and the entire configuration of the system of international relations in South Caucasus (SC) region. At the same time its consequences both for the regional situation and for the policies of the individual countries of the SC remain largely unclear. Thus the acute internal political crisis in Armenia has become protracted. There is still no unity among the parties concerned regarding the future of Nagorno-Karabakh. Apparently the outcome of the war will also entail noticeable shifts in the policy of extra-regional actors in the South Caucasus whose interests in one or other extent are affected by the conflict. However, the prospects for these changes are also still unclear. These and other problems related to the war in Karabakh and its consequences were the subject of discussion took place at the Institute of Oriental Studies of Russian Academy of Sciences (RAS) in January 14, 2021. The discussion was attended by A.B. Krylov, V.M. Mukhanov, S.A. Pritchin, A.Yu. Skakov (IMEMO RAS); S.M. Markedonov, A.A. Yarlykapov (MGIMO of Russian Ministry of Foreign Affairs).