Abstract. It is a well-established tradition of the Institute of World Economy and International Relations of Russian Academy of Sciences (IMEMO) to study the world’s major social and economic trends while taking into full account the most actual problems of Russia. In 2000s the government announces the course on innovative modernization as the basis for the long-term development strategy of the Russian Federation. Accordingly, the task of monitoring and application of the world experience of regulating this sphere took a priority place among the directions of the Institute’s research activities. The previous article published by ““World Economy and International Relations” Journal in 2006 in connection with the 50-anniversary of IMEMO exposed the principal stages of the examination of the economic aspects of scientific and technological progress (NTP). The IMEMO researchers proposed a radical change in the conceptual approach to respective studies – from NTP to innovations. This ensured a new and highly productive vision of the science, the technology trends and the innovative entrepreneurship within the concept of national innovation systems (NIS). This article is a continuation of the topic while summarizing the results of theoretical and applied research conducted by the team of the Department of Science and Innovation of the IMEMO in the past 10 years during 2005-2015.