Abstract. Washington’s strategic course in Central Asia is primarily aimed at weakening China in the region, being an integral part of the anti-Chinese trend of Donald Trump's policy. At the same time, it pursues the goal of weakening the role of Russia, which is a constant of the US policy. Relations with the regional countries are actualized by the  “Afghanistan factor” in connection with the impending withdrawal of the American contingent from the IRA. Uzbekistan is considered by Washington as an outpost of its policy in Central Asia, primarily in the Afghan direction. In Kazakhstan, the United States concentrat on promoting anti-Chinese sentiments. Despite the fact that relations with three other countries in the region remain on the periphery of Washington's policy, their development is envisaged by the framework of the C5 + 1 format.