Abstract. The article analyzes new trends in the foreign policy strategy of the Republic of Uzbekistan under the administration of President Shavkat Mirziyoyev. Central Asia is determined as Uzbekistan`s priority, the range of bilateral and multilateral relations with Russia, China, USA and others is expanding. The foreign policy vector of the development of Uzbekistan is undergoing changes taking into account the transformation of international and regional processes. That testifies to the desire of Uzbekistan to maintain geopolitical equilibrium in Central Asia, to form a balanced multifaceted system of relations with leading countries of the world and international organizations.