Analysis of the essence, content and forms of the scenario state of Japan in 2040, reflected in the 11th Scientific and TechnicalForecast of NISTEP in 2019, revealed a number of conceptual dialectical contradictions. They narrow down to the question of admissibility and expediency of changing a man's nature in order to ensure his prosperous, safe, meaningful and happy existence. The author proposes for discussion a conclusion on inevitability of the transhumanization of a mankind on the scale of a single country (Japan) and the whole world, given the nature of the great challenges facing it. The possibility of keeping the historical development in a conditionally humanistic direction is noted, given the emphasis of social reforms in Japan, reflected in the 6th Basic Plan for scientific, technical and innovative development of the country, on building a society for the fullest realization and use of human intellectual potential.