Today Russia has difficulty doing business-as-usual with EU states. It seems that the countries of the Visegrad Group (V4) and the Baltic Assembly/Baltic Council of Ministers (BA/BCM) have contributed substantially to this state of affairs. Overall, the tensions between Russia and the EU are building up - another tendency that did not arise on the Russian initiative. This article aims to address the question of whether Russia should establish direct relations with the V4 and the BA/BCM as tools to overcome the mentioned difficulties. On the one hand, these associations date back to before the countries acceded to the Union. On the other, they are products of regionalisation in the EU. In answering this question, we achieve three objectives. Firstly, we look for an appropriate theoretical and methodological framework for the study. Secondly, we produce a comparative description of the V4 and the BA/BCM. Thirdly, we examine the capacity of these associations to pursue an independent foreign and domestic policy. This study uses a comparison method to analyse the activities of the two organisations and identify their significance for the EU.