The last decade in the Central Asian region has been characterized by a steady trend of increasing fresh water needs due to the expansion of agricultural activities and the growth of population consumption. At the same time, the growth of consumption is ensured exclusively by increasing the anthropogenic load on available water resources, which causes a multiple increase in the risks of environmental disasters and problems with water supply and ensuring water security of the countries of the region. The article uses the method of complex assessment (balance method) of assessing the level of water resources availability in the context of countries, content analysis of regulation of water use of transboundary rivers, factor analysis of the growth of regulation of water flows of the main rivers (Amu Darya and Syr Darya basins, hereinafter abbreviated as BAM) and project analysis of the growth of anthropogenic pressure on the resource base of the region. The study notes that the uncoordinated use of water resources for national development and projects to overcome the environmental problems of shallowing of the Aral Sea only lead to an aggravation of the situation. The conclusions are based on the assessment of projects and strategies for overcoming the environmental catastrophe of the Aral Sea and the construction of new artificial water drainage infrastructure in the countries of the lower reaches of transboundary rivers.