Both Sub-Saharan Africa and Central Asia, once regarded as regions of peripheral significance by the United States, are increasingly being acknowledged as important areas, or areas of “greater significance”, in the context of efforts to contain China. However, the formulation of competitive initiatives in these regions presents challenges due to the necessity for a strategic shift in approach and the historical imbalance in attention afforded to international political developments on a broader scale. The article examines how the growing China’s influence affects American regional strategy and delineates the key dilemmas in approaches towards Central Asia and Sub-Saharan Africa in US Containment of PRC.