Being fully aware that the political strategy is a complex of many components, the author proceeds from the view that under certain conditions the great powers are inclined to use in their foreign policy strategy various methods and means that do not always correspond to the norms and rules of mutually beneficial cooperation. The author refers to them the demonization by the leadership of the US the opponents, first of all, the Russian Federation, considered to be the main enemy. The main focus is on substantiating the thesis that in recent years Washington's use of Russia's demonization, supplemented by attempts to dehumanize and delegitimize it, has taken on an unprecedented scale. For this, the latest information and ideological warfare is used, such as pseudo-events or fake proofs from scandalously known Powell test tubes prior to accusations of Russia's hacker intervention in the US presidential election in 2016, imitation of poisoning of the father and the daughter Scripals in Salisbury and etc.