The article examines the experience and models of structuring of transnational political spaces in Latin America and identifies the main actors of this process - both regional and external. The analysis of the major trends of the last decades is accompanied by a historical excursus which helps understand and evaluate factors which favor/hinder the integration processes at regional and subregional levels. The analysis of different projects of economic and political integration in the region raises the question whether Latin America can be hypothetically considered an international political region (a certain form of transnational political space), or the Latin American countries are increasingly drawn to the orbit of other emerging political spaces (subregional and biregional).