The article deals with the institutional structure of international trade. The analysis includes the major factors of the current crisis of the World Trade Organization and the causes that hinder the course of the Doha Round of multilateral trade negotiations. Consideration is given to such factors as the crisis of 2008-2009, strengthening of developing countries’ positions, creation of new regional trade blocs, transnational production and global value chains. It is noted that despite the breakthrough at the WTO Conference in Bali the main reasons of crisis of the institutional structure of international trade are still to be overcome.