Pandemic COVID-19 has become a difficult test for the countries of the Visegrad Group. It was the tragic cause of numerous human losses and economic losses, but at the same time gave a new impetus to subregional cooperation in the fight against the infectious threat and its consequences. Since the end of 2020, the pledge of victory over the disease has become a mass vaccination. The main conditions for its conduct are beyond the resource potential of the Visegrad states and transfer the medical and social problem to the sphere of geopolitics. The behavior of the group member countries marked a whole range of approaches to solving an arisen problem. The most unequivocal position was occupied by the Poland authorities that use for vaccinations exclusively drugs approved by Brussels. In Hungary initially existed a flexible approach to the problem of vaccination funds, which corresponded to the pragmatic installations of the government of Viktor Orban. The beginning of mass vaccination in the Czech Republic and Slovakia, on the contrary, was accompanied by a series of scandals and fierce internal political confrontation. The conflicting parties here were not simply supporters and opponents of using the Russian vaccine, but carriers of various views on the strategy of relations with Moscow.