A fundamental change in personnel policy in the management of healthcare systems is expected around the world, associated with the transition of the industry to a new technological level. In this regard, the need to expand the problem field of the study of labor relations in this area is becoming relevant. The subject of the study is the personnel potential for the formation of a new landscape of healthcare. This paper aims to identify opportunities to overcome the risks associated with the growing shortage of healthcare professionals in the world. The scientific novelty lies in the identification of the most acute social aspects of the bio-information transformation taking place in the healthcare field. The author uses the methods of source study and statistical analysis of a wide range of sources: scientific literature, statistical data, and sociological research data. The paper analyzes data that reflect the growing concern of the medical community with the problems of turnover of healthcare personnel, medical education, and labor protection of the interests of healthcare workers. The author reveals the existing barriers in training and retraining personnel, as well as the need to develop new approaches to the labor protection of healthcare workers. As a result of the study, the author concludes that at this stage it is not possible to address the shortage of healthcare workers by attracting them from less developed regions to economically prosperous ones. The extraordinary circumstances caused by the COVID-19 pandemic have not only shown the world all the issues of today's healthcare systems but also opened up opportunities for healthcare leaders to revise the long-term vision of solving workforce problems based on lessons learned. The article shows that the burden associated with the need to quickly solve many administrative tasks associated with the COVID-19 pandemic required a significant increase in state regulation of the industry. The study's findings can be useful to employees of various federal structures of the Russian Federation in both applied and forecasting activities on the way to solving the problems of staffing the industry. The ideas proposed by the author can be in demand by representatives of the scientific and educational community and trade union leaders directly involved in protecting the interests of healthcare workers.