At present, the American political and intellectual elites continue to actively implement the concept of the Indo-Pacific Region (IPR, Indo-Pacific) as a wider geopolitical and geo-economic space than the Asia-Pacific. The article retrospectively examines the formation of the concept of the Indo-Pacific region under previous American presidents, analyzes the current strategy, and sums up the interim results of US foreign policy in the region. Using the system-historical method of research, the author comes to the conclusion about the continuity of the American political course in the Indo-Pacific region based on bilateral security treaties with allies and flexible multilateral alliances.